Northeastern University, United States
Nikolai Slavov received BS from MIT in 2004 and then pursued doctoral research in the Botstein laboratory at Princeton University, aiming to understand how cells coordinate their growth, gene expression, and metabolism. As a postdoc in the van Oudenaarden laboratory at MIT, Dr. Slavov characterized trade-offs of aerobic glycolysis (also known as Warburg effect). Nikolai Slavov obtained direct evidence for differential stoichiometry among core ribosomal proteins, suggesting that specialized ribosomes regulate protein synthesis. These results were awarded the NIH Director’s award and established the lab’s ongoing research on ribosome-mediated translational control. The Slavov laboratory pioneered methods for high-throughput quantification of proteins at single-cell resolution and used them to quantify thousands of proteins in differentiating cells. These data have enabled characterizing post-transcriptional regulation in single cells at systems level, as well as discovering macrophage polarization in the absence of polarizing cytokines.