Melvin Park

Mel Park and Oliver Raether are recognized for the commercialization of the Trapped Ion Mobility Spectrometry (TIMS) Parallel Accumulation Serial Fragment (PASEF) method which takes advantage of the unique features of the TIMS device to improve MS/MS sequencing speed and sensitivity on QTOF Instruments. TIMS was developed as a compact and convenient way to perform true ion mobility measurements using an electric field gradient to trap ions in a flowing gas. A 5 cm TIMS device achieves the same resolution as a 2-meter-long drift tube ion mobility system, without the high voltages and ion losses. Coupling the TimsTOF PASEF method is transformative with the combination of increased MS/MS speed with improved sensitivity is helping to revolutionize the field of proteomics improving proteome coverage and sample throughput such as studies of large clinical cohorts, e.g; plasma proteomics or urine proteomics. High sensitivity proteomics for single cell, immunopeptidomics and proteomics of tissue biopsies, label free quantitation, SILAC, DIA and PRM proteomics are all applicable to the TimsTOF PASEF instrument.