Chair: Cecilia Lindskog, Sweden
Co-Chair: Deborah Penque, Portugal
ATLANTiC: Proteome Activity Landscapes of Tumor Cell Lines Determine Drug Responses, Bernhard Kuster, Germany
Deep Visual Proteomics for Systems Biology, Matthias Mann, Germany
Regulation of Hypoxia-inducible Factors by Oxygen-dependent Degradation, Gregg Semenza, United States

This session is supported by:

Chair: Michelle Hill, Australia
Co-Chair: Nicolai Bache, Denmark
Development of a Pan-coronavirus Proteome Serological Assay, Josh LaBaer, United States
The 3D Proteome and the Potential for Conformational Biomarkers, John Yates, United States
Protein Biomarker Quantification by LCMS Enabling Gene Therapy and Biotherapeutics Development in Biopharma, Hendrik Neubert, United States

This session is supported by:

Chair: Paola Roncada, Italy
Co-Chair: Fábio CS Nogueira, Brazil
In-cell Protein Footprinting: A Tool for Structural Biology Across the Proteome, Lisa Jones, United States
Single-cell Proteomic and Transcriptomic Analysis of Macrophage Heterogeneity, Nikolai Slovov, United States
Mass Spectrometry Proteomics for Single-cell Neuroscience, Peter Nemes, United States

This session is supported by:

Live Annual General Meeting and Kahoot Quiz

Chair: Giuseppe Palmisano, Brazil
Finalists:
Precision Mapping of O Linked N Acetylglucosamine Sites in Proteins Using Ultraviolet Photodissociation Mass Spectrometry, Edwin Escobar, United States
A Versatile Isobaric Tag Enables Proteome Quantification in Data Dependent and Data Independent Acquisition Mode, Xiaobo Tian, The Netherlands
Ion Mobility Separation in a TIMS-TOF PASEF Acquisition Method Decreases Spectral Complexity, Joshua Charkow, Canada
Protein Context Shapes the Specificity of Domain-Peptide Interactions in Vivo, Ugo Dionne, Canada
Spatially Resolved Proteome Profiling of FFPE Tissues, Andikan Nwosu, United States
Dissecting the Ontogenic Remodeling of the Proteomic Landscape and Functionality of Hematopoietic Progenitor Cells in Normal Development and Leukemia, Maria Jassinskaja, Sweden
Identification of Autoantigens with Diagnostic Ability of Colorectal Cancer by Immunoprecipitation Coupled to Mass Spectrometry, Ana Montero Calle, Spain
Preservation of Trypsin Activity at Elevated Temperatures for Optimized Proteome Digestion, Jessica Nickerson, Canada

The Synergies of Mass Spectrometry and Informatics, John R. Yates
New prm-PASEF® Method for Highly Multiplexed Targeted Quantitative Proteomics for Clinical Research, Gunnar Dittmar

This industry seminar is supported by:
For more details on the virtual Industry Seminars, please visit the Confirmed Sponsors & Virtual Seminars page.

Chair: Rob Mortiz, United States
Co-Chair: Maggie Lam, United States
ATLANTiC: Proteome Activity Landscapes of Tumor Cell Lines Determine Drug Responses, Bernhard Kuster, Germany
Deep Visual Proteomics for Systems Biology, Matthias Mann, Germany
Regulation of Hypoxia-inducible Factors by Oxygen-dependent Degradation, Gregg Semenza, United States

This session is supported by:

Chair: Susan Weintraub, United States
Co-Chair: Justyna Fert-Bober, United States
Development of a Pan-coronavirus Proteome Serological Assay, Josh LaBaer, United States
The 3D Proteome and the Potential for Conformational Biomarkers, John Yates, United States
Protein Biomarker Quantification by LCMS Enabling Gene Therapy and Biotherapeutics Development in Biopharma, Hendrik Neubert, United States

This session is supported by:

Chair: Fernando Corrales, Spain
Co-Chair: Michael Roehrl, United States
In-cell Protein Footprinting: A Tool for Structural Biology Across the Proteome, Lisa Jones, United States
Single-cell Proteomic and Transcriptomic Analysis of Macrophage Heterogeneity, Nikolai Slovov, United States
Mass Spectrometry Proteomics for Single-cell Neuroscience, Peter Nemes, United States

This session is supported by:

Chair: Mathieu Lavallée-Adam, Canada
Career, Family and Work-Life, Balance, Benjamin A. Garcia, United States
Work-Life Balance Especially During the COVID-19 Pandemic, Ruth Huttenhain, United States

Live Annual General Meeting and Kahoot Quiz

Chairs: Maike Langini, Germany, Andreas Hober, Sweden
The Industry Needs You, Bernard Delanghe, United States
Publishing: A Career Beyond Academia, James Anson, United Kingdom

Chair: Peter Hoffman, Australia
Co-Chair: Maike Langini, United Kingdom
Rapid Complex-centric Quantitative Profiling of the Monocyte-macrophage Axis, Ben Collins, United Kingdom
Proteomes in 3D, Paola Picotti, Switzerland
Cellular Cartography Using Crosslinking Mass Spectrometry, Juri Rappsilber, United Kingdom

Chair: Andrea Urbani, Italy
Co-Chair: Chia-Li Han, Taiwan
Computational Discovery of Tumor Antigens from Mass Spectrometry Data, Bing Zhang, United States
Exploring the Landscape of Pan-cancer Proteogenomics with Cancer Cell Lines, Rebecca Poulos, Australia
Genetics of Protein Abundance in Human TIssues, Hua Tang, United States

Chair: Ileana Cristea, United States
Co-Chair: James Waddington, Ireland
Defining Proteoform Landscape by Novel Top-down Proteomics Strategies, Ying Ge, United States
Building an Ecosystem to Measure and Understand Human Biology at the Proteoform Level, Neil Kelleher, United States
Challenges to Unveil Human Proteoform Landscape by Shotgun Proteomics Approaches, Yasushi Ishihama, Japan

Chairs: Maike Langini, Ruth Huttenhain
Mechanism of adrenergic CaV1.2 stimulation revealed by proximity proteomics, Marian Kalocsay, United States
Sleep-wake cycles drive daily dynamics of synaptic phosphorylation, Maria Robles, Germany
The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest, Jakob Trendel, Germany

Multi-omic analysis of two common p53 mutations: Proteins regulated by mutated p53 as potential targets for immunotherapy, Christie Hunter, David Boocock
This industry seminar is supported by:
For more details on the virtual Industry Seminars, please visit the Confirmed Sponsors & Virtual Seminars page.

Multiplexed Proteomics for Understanding Molecular Biology, Mikhail Savitski, Denmark
Characterizing Cellular Hierarchies Using Quantitative Single-Cell Proteomics, Erwin Schoof, Germany

This industry seminar is supported by:
For more details on the virtual Industry Seminars, please visit the Confirmed Sponsors & Virtual Seminars page.

Chair: Gyorgy Marko-Varga, Sweden
Co-Chair: Svetlana Murzina, Russia
Rapid Complex-centric Quantitative Profiling of the Monocyte-macrophage Axis, Ben Collins, United Kingdom
Proteomes in 3D, Paola Picotti, Switzerland
Cellular Cartography Using Crosslinking Mass Spectrometry, Juri Rappsilber, United Kingdom

Chair:Henry Rodriguez, United States
Co-Chair: Tim Van Den Bossche, Belgium
Computational Discovery of Tumor Antigens from Mass Spectrometry Data, Bing Zhang, United States
Exploring the Landscape of Pan-cancer Proteogenomics with Cancer Cell Lines, Rebecca Poulos, Australia
Genetics of Protein Abundance in Human TIssues, Hua Tang, United States

Chair: Frank Schmidt, Qatar
Co-Chair: Ruth Huttenhain, United States
Defining Proteoform Landscape by Novel Top-down Proteomics Strategies, Ying Ge, United States
Building an Ecosystem to Measure and Understand Human Biology at the Proteoform Level, Neil Kelleher, United States
Challenges to Unveil Human Proteoform Landscape by Shotgun Proteomics Approaches, Yasushi Ishihama, Japan

Closing Remarks
Announcement of the PhD Poster and ECR Manuscript Winners
HUPO Awards
Ben Collins, Ireland
Benjamin A. Garcia, United States
Fuchu He, China
Karin Rodland, United States
Melvin Park, United States
Oliver Raether, United States
Tadashi Yamamoto, Japan
Announcement of HUPO 2021 Programme

Chairs: Robert Moritz, United States, Sue Weintraub, United States
Relevance and Future Projections of Proteomics in the Pharmaceutical Industry, Jennie Lil, United States
Translating Proteomics to the Clinical Arena, Michael Roehrl, United States
Target 2035 - Pharmacological Modulators for All Human Proteins, Cheryl Arrowsmith, Canada
Expanding Proteomics Beyond the Proteomic Community, Jochen Schwenk, Sweden
Bringing context to substance, Relevance of the Human Proteome Project, Robert Moritz, United States
Review and Updates (Future Planning/Developments)
- C-HPP, Chris Overall, United States
- B/D-HPP, Ileana Cristea, United States
- Initiatives and 4 Resource Pillars, Cecilia Lindskog, Sweden, Eric Deutsch, United States, Lydie Lane, Switzerland, Ed Nice, Australia, Michael Roehrl, United States and Susan Weintraub, United States
Written Questions from the Floor

Chairs: Ruedi Aebersold, Switzerland, Rebekah Gundry, United States
Background and Outline, Ruedi Aebersold, Switzerland
SAB Session with 3 Break-Out Groups, All
- Breakout I. How can proteomics make the link from measuring molecules (proteins) to biological function?
Rapporteur:Juri Rappsilber, Germany
- Breakout II. HPP can claim that the discovery of exemplary proteins from almost all human loci can be confidently detected and routinely measured. How does HPP build on that to advance life science and clinical research? In other words, how can we explore ( e.g. within HPP) the full extent of the complexities of the proteome and how can this be translated into new biology?
Rapporteur: Kathryn Lilley, UK
- Breakout III. What are the bottlenecks to increase the uptake and dissemination of proteomics?
Rapporteur: Cathy Costello, United States
Summary Reports to Combined Group, All

Chairs: Cecilia Lindskog, Sweden, Ed Nice, Australia
Human Cell Atlas/Chan Zuckerberg Foundation/International Opportunities, Emma Lundberg, Sweden, Neil Kelleher, United States
International HUPO External Development Initiative Panel, Sudhir Srivastava, United States, Sanjeeva Srivastava, India,
Kristin E Burnum-Johnson, United States, Eleftherios Diamandis, Canada, Anthony Whetton, United Kingdom
USA and Cancer Moonshot Opportunities, Mike Snyder, United States, Henry Rodriguez, United States
Other Opportunities from the Floor
Incoming HUPO Presidential Address to the HPP, Yu-Ju Chen, Taiwan