Announcing the Human Proteome Project (HPP) Blueprint
Human 10th birthdays mark a very special tradition – from a learning-packed early childhood to wonderfully exhilarating teenage years. Similarly, at the 19th Human Proteome Organization World Congress in Stockholm, the Human Proteome Project (HPP) celebrates this milestone decadal birthday by releasing the first community-endorsed blueprint draft of the human proteome.
It was only two decades ago that a company (Celera Genomics) and public rivalry under the Human Genome Project assembled the draft human genome. This contained far fewer protein-coding genes than was anticipated and was jam-packed with gaps and ambiguities. Recent analysis suggests that the human genome only codes for approximately 20,000 proteins. Arms with the draft genome, the first challenge was to assemble a parts-list blueprint for the human proteome. This initial phase involved an unparalleled collaborative enterprise, this time involving scientists from over 100 countries with various skill sets, freely uploading and then communally analyzing their data. This now culminates in a high-precision human proteome knowledge base.
Some sought to find the elusive missing proteins which dodge discovery, whilst others sought to appreciate how human proteome worked or how it could be harnessed to better diagnose and treat cancer, Alzheimer’s, heart attacks, diabetes, and other diseases.
The Human Proteome Project (HPP)'s Mission Statement
By characterizing all 20,300 genes of the known genome, the Human Proteome Project will generate the map of the protein based molecular architecture of the human body and become a resource to help elucidate biological and molecular function and advance diagnosis and treatment of diseases.
The Human Proteome Project (HPP) is an international project organized by the Human Proteome Organization (HUPO) that aims to revolutionize our understanding of the human proteome via a coordinated effort by many research laboratories around the world. It is designed to map the entire human proteome in a systematic effort using currently available and emerging techniques. Watch the video below for more information!